Peptide fragments for inducing synthesis of extracellular matrix proteins

摘要

Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

主权项

1. A composition comprising at least one tetrapeptide capable of inducing production of extracellular matrix proteins, wherein the amino acid sequence of the tetrapeptide consists of SEQ ID NO:1 or SEQ ID NO:14, said sequence having an amidated carboxy-terminus, and a pharmaceutically acceptable carrier.