发明名称 |
Thienopyridazine compounds, their preparations, pharmaceutical compositions and uses |
摘要 |
The present invention relates to thienopyridazine compounds of formula (I), their pharmaceutically acceptable salts or hydrates, wherein R1 and R2 are independently H or C1-4 alkyl, R3 is a saturated or unsaturated 5- or 6-membered ring containing N, S or O, or its optical isomers, R4 is a halophenyl monosubstituted or disubstituted at any position. The present invention provides the preparation methods of these compounds, pharmaceutical compositions containing these compounds and the uses of these compounds, particularly in treating cancer.; |
申请公布号 |
US8962626(B2) |
申请公布日期 |
2015.02.24 |
申请号 |
US200912811898 |
申请日期 |
2009.01.07 |
申请人 |
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory |
发明人 |
Wu Zhanggui |
分类号 |
A01N43/58;A01N43/60;A61K31/50;A61K31/495;C07D237/26;C07D487/00;C07D237/28;C07D495/04 |
主分类号 |
A01N43/58 |
代理机构 |
Lipton, Weinberger & Husick |
代理人 |
Tankha Ash;Lipton, Weinberger & Husick |
主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable salt or a hydrate thereof, wherein, R1 and R2 are independently H or C1-4 alkyl; R3 is hexahydropyridinyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydropyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, pyridinyl, α-pyranyl, γ-pyranyl, α-thiopyranyl, γ-thiopyranyl, pyrrolidinyl, furanyl, or thienyl and an optical isomer thereof; R4 is a halophenyl monosubstituted or disubstituted at any position. |
地址 |
Xinchang County, Zhejiang Province CN |