Method for applying flowable hydrogels to a cornea

摘要

Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages. A method of treating a patient by application of a hydrogel bandage to a cornea by providing a first hydrogel precursor in a dry form immobilized in a first deposit at a first location in a well, providing a second hydrogel precursor in a dry form immobilized in a second deposit at a second location in the well, mixing the deposits together to form a mixture, and transferring at least some of the mixture to the cornea, with the mixture forming a covalently crosslinked hydrogel on the cornea.

主权项

1. A method of treating a patient by application of a hydrogel bandage to a cornea comprising:
providing a first hydrogel precursor in a dry form immobilized in a first deposit at a first location in a well, providing a second hydrogel precursor in a dry form immobilized in a second deposit at a second location in the well, adding less than 1000 μl of aqueous solution to one or more of the deposits to thereby dissolve the first and/or the second hydrogel precursor; mixing the deposits together to form a mixture comprising the first hydrogel precursor and the second hydrogel precursor, introducing a delivery surface to the mixture and recovering a volume between 1 and 100 μl of the mixture transferring at between 1 and 100 μl of the volume from the delivery surface to the cornea, with the mixture forming a covalently crosslinked hydrogel on the cornea, wherein said immobilization prevents the hydrogel precursor from moving from the location until such time as it is dissolved in the aqueous solution and wherein said immobilization prevents the first hydrogel precursor in the dry form and the second hydrogel precursor in the dry form from mixing together before being dissolved.