发明名称 |
Chemical probe compounds that become fluorescent upon reduction, and methods for their use |
摘要 |
Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents. |
申请公布号 |
US8962853(B2) |
申请公布日期 |
2015.02.24 |
申请号 |
US201313975675 |
申请日期 |
2013.08.26 |
申请人 |
Life Technologies Corporation |
发明人 |
Cheung Ching-Ying;Gray Diane;Yue Stephen |
分类号 |
C07D291/00;C07C211/00;G01N33/58;C07D211/62;C07D295/112;C07D417/06;C07D417/14;C09B23/04;C12Q1/04;C12Q1/18;G01N33/52 |
主分类号 |
C07D291/00 |
代理机构 |
Life Technologies Corporation |
代理人 |
Life Technologies Corporation |
主权项 |
1. A chemical compound having the structure: |
地址 |
Carlsbad CA US |