| 发明名称 | Surface-coated structures and methods | ||
| 摘要 | The present invention relates to a method for covalently attaching a compound to a stainless steel, tin, iron, or titanium substrate, by contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide loop derived from the C-terminal receptor binding protein of Type IV P. aeruginosa (T4P) pilin, to bind the pilin peptide to the exposed surface(s), and covalently attaching the compound to the pilin peptide. Also disclosed are a substrate formed by the method and a biosensor device that uses the uses. Also disclosed are methods for improving the corrosion resistance, adhesive force, hardness and electron work function of certain metals. | ||
| 申请公布号 | US8961984(B2) | 申请公布日期 | 2015.02.24 |
| 申请号 | US201012899958 | 申请日期 | 2010.10.07 |
| 申请人 | Arch Biophysics, Inc. | 发明人 | Irvin Randall T.;Davis Elisabeth M.;Li DongYang |
| 分类号 | A61K39/00;A61K39/108;A61K39/02;C07K14/21;A61B5/145;A61L27/04;A61L27/34;A61L27/54;A61L31/02;A61L31/04;A61L31/10;A61L31/16;C12N15/10 | 主分类号 | A61K39/00 |
| 代理机构 | King & Spalding | 代理人 | King & Spalding |
| 主权项 | 1. A method of covalently attaching a compound to one or more exposed surfaces of a substrate formed of stainless steel, tin, iron, or titanium, comprising contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide loop having the sequence identified as SEQ ID NO:10 and containing 0-10 additional residues on either or both the N- or C-terminal side of the loop, thereby to bind the pilin peptide covalently to the exposed surface(s), and before or after said contacting and binding, covalently attaching the compound to the pilin peptide. | ||
| 地址 | Alberta CA | ||