发明名称 |
Synthesis of iodixanol in methanol |
摘要 |
This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent. |
申请公布号 |
US8962886(B2) |
申请公布日期 |
2015.02.24 |
申请号 |
US200912621551 |
申请日期 |
2009.11.19 |
申请人 |
GE Healthcare AS |
发明人 |
Johnsen Hanne Jorunn H.;Holmaas Lars Terje;Homestad Ole Magne |
分类号 |
C07C233/64;C07C231/12 |
主分类号 |
C07C233/64 |
代理机构 |
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代理人 |
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主权项 |
1. A process for the dimerisation of 5-acetamido-N,N′-bis (2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound A) in a temperature range of about 10 to about 20° C. using methanol as solvent in a concentration of about 0.8 to 2.0 ml solvent per g Compound A in the presence of about 0.30 to 0.36 mole equivalents of epichlorohydrin relative to Compound A, and wherein the reaction solution has a pH value of about 11.5 to about 12.2, whereby the pH is varied throughout the dimerisation having a higher value at the start of the dimerisation than at the end thereof, and wherein the amount of backpeaks does not exceed 2% at 55-60% conversion of Compound A to iodixanol. |
地址 |
Oslo NO |