主权项 |
1. A compound of the formula I:or pharmaceutically acceptable salt thereof, wherein:
ring A is phenyl; p is 0, 1, 2 or 3; q is 0, 1, 2 or 3; X is selected from the group consisting of hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halo, nitro, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkynyl, substituted cycloalkynyl; Y is alk-SO2N(R4)R5 or alk-N(R4)SO2R5; alk is selected from the group consisting of straight or branched chain C1-6 alkylene group, cycloalkylene and substituted cycloalkylene; R1 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkynyl, substituted cycloalkynyl, cycloalkyl and substituted cycloalkyl; each R2 independently is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkynyl, substituted alkynyl, cycloalkynyl, substituted cycloalkynyl, alkynyloxy, amino, substituted amino, aryl, substituted aryl, aryloxy, substituted aryloxy, cyano, cycloalkyl, substituted cycloalkyl, cycloalkoxy, substituted cycloalkoxy, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, aminoacyl, aminoacyloxy, carboxyl, carboxyl ester, carbonate ester, nitro, and halo; Z1, Z2, and Z3 each independently is carbon or nitrogen, wherein no more than one of Z1, Z2, and Z3 is N; each R3 independently is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkynyl, substituted alkynyl, cycloalkynyl, substituted cycloalkynyl, alkynyloxy, amino, substituted amino, aryl, substituted aryl, aryloxy, substituted aryloxy, cyano, cycloalkyl, substituted cycloalkyl, cycloalkoxy, substituted cycloalkoxy, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, aminoacyl, aminoacyloxy, carboxyl, carboxyl ester, carbonate ester, nitro, halo and aminosulfonyl; or R6 and one of R3, together with the intervening atoms bound thereto form a heterocyclic or a substituted heterocyclic fused to the ring containing Z1, Z2 and Z3; or R7 and one of R3, together with the intervening atoms bound thereto form a heterocyclic or a substituted heterocyclic fused to the ring containing Z1, Z2 and Z3; or R4 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, acyl and M+, wherein M+ is a counterion selected from the group consisting of K+, Na+, Li+ and +N(R8)4, wherein R8 is hydrogen or alkyl, and the nitrogen of —SO2N(R4)R5 or —N(R4)SO2R5 is N−; R5 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, amine, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and acyl; or
R4 and R5 together with the intervening atom or atoms bound thereto form a heterocyclic or a substituted heterocyclic group; R6 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, carboxyl, carboxyl ester, aryl, substituted aryl, heteroaryl, substituted heteroaryl, acyl and M+, wherein M+ is a counterion selected from the group consisting of K+, Na+, Li+ or +N(R8)4, wherein R8 is hydrogen or alkyl, and the nitrogen of —SO2N(R6)R7 or —N(R6)SO2R7 is N−; or
R6 and R7 together with the intervening atom or atoms bound thereto, form a heterocyclic or a substituted heterocyclic group; and R7 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, amine, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, carboxyl, carboxyl ester, and acyl. |