发明名称 |
Methods useful for vitamin D deficiency and related disorders |
摘要 |
Methods for diagnosing, treating, and preventing catabolism-related vitamin D deficiency and related disorders, related compositions, apparatus and kits, are disclosed. A method involves measuring CYP24 expression and/or activity, or a proxy thereof such as FGF23 level, in a patient and correlating abnormally elevated CYP24 expression and/or activity with catabolism-related vitamin D deficiency or with susceptibility for catabolism-related vitamin D deficiency. In response to abnormally elevated CYP24 expression and/or activity, the method further includes administering a CYP24 inhibitor to the vitamin D deficient or at-risk patient, and preferably avoiding activation of the vitamin D binding receptor, such as by avoiding administration of active vitamin D compounds to such patients. Optionally, a vitamin D prohormone or prohormone can be administered. |
申请公布号 |
US8962239(B2) |
申请公布日期 |
2015.02.24 |
申请号 |
US200912935139 |
申请日期 |
2009.04.02 |
申请人 |
Opko Renal, LLC;Opko IP Holdings II, Inc. |
发明人 |
Petkovich P. Martin;Helvig Christian F.;Melnick Joel Z. |
分类号 |
C12Q1/68;G01N33/53;G01N33/573;A01N45/00;A61K31/00;A61K45/06;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
Marshall, Gerstein & Borun LLP |
代理人 |
Marshall, Gerstein & Borun LLP |
主权项 |
1. A method of diagnosing and treating catabolism-related vitamin D deficiency or a susceptibility thereto in a patient having Chronic Kidney Disease, comprising:
requesting a test providing the results of a measurement, direct or indirect, of a patient's CYP24 expression and/or activity, wherein abnormally elevated CYP24 expression and/or activity indicates a susceptibility for catabolism-related vitamin D deficiency; and administering an effective amount of a pharmaceutically acceptable formulation comprising a CYP24 inhibitor to the patient in response to abnormally elevated CYP24 expression and/or activity to treat or prevent catabolism-related vitamin D deficiency defined as a total serum level of 25-hydroxyvitamin D below 30 ng/mL. |
地址 |
Miami FL US |