Electrochemical analyte measurement method and system

摘要

Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration.

主权项

1. A method for determining a glucose concentration measurable with a system having a test strip and a meter having a test circuit including a microprocessor, the method comprising:
applying, with the test circuit, a first test voltage between a reference electrode and a second working electrode coated with a reagent layer of the test strip and applying a second test voltage between the reference electrode and a first working electrode coated with a reagent layer; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample is applied to the test strip; measuring a fifth test current at the first working electrode; determining, with the microprocessor, a glucose concentration based on the first, second, third, fourth and fifth test currents; andannunciating the glucose concentration, in which the glucose concentration comprises a value obtained with an equation of the form:G=[(I1I2)(a-b⁢I3I4)⁢xI5]-interceptslope where: G is the glucose concentration; I1 is the first test current; I2 is the second test current; I3 is the third test current; I4 is the fourth test current; I5 is the fifth test current; a is a first tuning parameter and b is a second tuning parameter; intercept is an intercept value determined from a linear regression of a plot of[(I1I2)(a-b⁢I3I4)⁢xI5]versus a reference glucose concentration; and
slope is a slope value determined from a linear regression of a plot of[(I1I2)(a-b⁢I3I4)⁢xI5]versus the reference glucose concentration.