Rapidly acting dry sealant and methods for use and manufacture

摘要

Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.

主权项

1. A dry solid sealant matrix composition comprising:
a first cross-linkable component; a second cross-linkable component; and a hydrogel-forming component characterized by an equilibrium swell value of between about 400% and about 1300%; wherein the concentration of combined first and second cross-linkable components is from 5% to 75% of the total mass of the composition and the concentration of the hydrogel-forming component is from 95% to 25% of the total mass of the composition; wherein the first and second cross-linkable components are configured to react by cross-linking upon contact between the dry solid sealant matrix composition and a tissue to form a porous matrix having interstices, and wherein the hydrogel-forming component is configured to swell, by absorption of moisture following the tissue contact to form a hydrogel to fill at least some of the interstices; wherein the first cross-linkable component comprises a multi-nucleophilic polyalkylene oxide having m nucleophilic groups, and the second cross-linkable component comprises a multi-electrophilic polyalkylene oxide having n electrophilic groups, wherein m and n are each greater than or equal to two, and wherein m+n is greater than or equal to five; and wherein the tissue comprises a bleeding site, and wherein the matrix and interstitial hydrogel are configured to seal the bleeding site.