| 发明名称 | Maintenance and propagation of mesenchymal stem cells | ||
| 摘要 | Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same. | ||
| 申请公布号 | US8961955(B2) | 申请公布日期 | 2015.02.24 |
| 申请号 | US201313762887 | 申请日期 | 2013.02.08 |
| 申请人 | The Board of Trustees of the University of Arkansas;The United States of America as Represented by the Department of Veterans Affair | 发明人 | Chen Xiao-Dong;Jilka Robert L. |
| 分类号 | C12N5/071;C12N5/0775;C12M3/00;C12M1/12 | 主分类号 | C12N5/071 |
| 代理机构 | Fulbright & Jaworski LLP | 代理人 | Fulbright & Jaworski LLP |
| 主权项 | 1. A bone forming composition comprising: (i) a cellular composition comprising undifferentiated mammalian mesenchymal stem cells that have been cultured on and then removed from a three-dimensional marrow stromal cell derived extracellular matrix, and (ii) a transplantation vehicle; wherein said extracellular matrix comprises type I collagen, type II collagen, type V collagen, syndecan-1, fibronectin, decorin, biglycan, perlecan, and laminin; and wherein said transplantation vehicle comprises a ceramic powder. | ||
| 地址 | Little Rock AR US | ||