Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin

摘要

A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.

主权项

1. A method of providing drug delivery capability for a stent, comprising:
coating a stent with a composition comprising a polymer and 40-O-(2-hydroxyl)ethyl-rapamycin, 40-O-(3-hydroxyl)propyl-rapamycin or 40-O-[2-(2-hydroxyl)ethoxy]ethyl-rapamycin; and exposing the coating to a sufficient temperature to cause modification to the polymer so as to reduce the rate of release of the drug; wherein the coating releases less than 50% of the total amount of the 40-O-(2-hydroxyl)ethyl-rapamycin, 40-O-(3-hydroxyl)propyl-rapamycin or 40-O-[2-(2-hydroxyl)ethoxy]ethyl-rapamycin in vivo in a first 24 hour period following an implantation procedure.