| 发明名称 | Method of treating a diabetic subject having a microvascular impairment disorder by a pegylated C-peptide | ||
| 摘要 | The present invention relates to PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit improved pharmacokinetic and biological activity in vivo. | ||
| 申请公布号 | US8962553(B2) | 申请公布日期 | 2015.02.24 |
| 申请号 | US201213680753 | 申请日期 | 2012.11.19 |
| 申请人 | Cebix AB | 发明人 | Wahren John;Barrack Sheri;Callaway James;Mazzoni Michelle;Foyt Howard;Daniels Mark |
| 分类号 | A61K38/28;A61P3/10;C07K17/02 | 主分类号 | A61K38/28 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method of treating a diabetic subject having a microvascular impairment disorder, comprising subcutaneously administering to the subject a therapeutically effective amount of PEGylated C-peptide, wherein the PEGylated C-peptide has the structure: wherein each R1 is alkyl; n1 is 200 to 800; n2 is 200 to 800; and the polyethylene glycol (PEG) moiety has a molecular weight of about 40 kDa to about 50 kDa. | ||
| 地址 | San Diego CA US | ||