Protein kinase inhibitors and methods of treatment

摘要

The present invention relates to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to substituted pyrazolo[3,4-d]pyrimidine based compounds which can be used in treating proliferative disorders, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.;

主权项

1. A compound of the following Formula (I):or a salt thereof, wherein:
R1 is selected from the group consisting of hydrogen, optionally substituted alkyl, —(SO2)-optionally substituted aryl, —(SO2)-optionally substituted heteroaryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aryl, and C(═X)—R6; R2 is selected from the group consisting of hydrogen and C1-C3 alkyl; R3 and R4 are independently C1-C3 alkyl; L is selected from the group consisting of a bond, —O—, —S—, —N(R9)—, optionally substituted alkylene, and —N(R9)C(X′)—N(R9′)—, where each of R9 and R9′ is independently hydrogen or C1-C4 alkyl; R5 is selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, and optionally substituted cycloalkyl; X and X′ are independently selected from the group consisting of O, S and NR7; R6 is selected from the group consisting of optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C2-C6alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted amino, optionally substituted acylamino, optionally substituted arylacyl, optionally substituted heteroarylacyl, optionally substituted heterocyclylacyl, optionally substituted cycloalkylacyl, and trihalomethyl; R7 is selected from the group consisting of hydrogen, cyano, optionally substituted C1-C6 alkyl, optionally substituted aryl, S(O)2R8, and optionally substituted aminoacyl; and R8 is selected from the group consisting of optionally substituted C1-C6 alkyl and optionally substituted aryl.