主权项 |
1. A compound according to formula (Ia), wherein A′ is —NH-L1-R7, wherein L1 is a linker selected from a bond or —C1-C2-alkylene, wherein R7 is a ring selected from among —C3-C8-cycloalkyl, —C3-C8-heterocyclyl, —C5-C10-aryl, and -C5-C10-heteroaryl, wherein the ring R7 is optionally substituted with one or more groups selected from among —CF3, —C1-C6-alkyl, —O—CF3, —CN, —O—C1-C6-alkyl, —C1-C6-alkenyl, and —C1-C6-alkynyl, and -halogen, or wherein the ring R7 is optionally substituted with one or more groups selected from among -C5-C10-aryl, -C5-C10-heteroaryl, —C3-C8-cycloalkyl, —C3-C8-heterocyclyl, optionally being substituted by one or more groups selected from among —OH, —NH2, —C1-C4-alkyl, —O—C1-C6-alkyl, —CN, —CF3, —OCF3, halogen, and ═O, or wherein the ring R7 is optionally further bi-valently substituted on two neighbouring ring atoms, such that an annellated ring is formed by one or more groups selected from among —C1-C6-alkylene, —C2-C6-alkenylene and —C4-C6-alkynylene, in which one or two carbon centers may optionally be replaced by 1 or 2 hetero atoms selected from N, O and S, the bivalent group being optionally substituted by one or more groups selected from —OH, —NH2, —C1-C4-alkyl, —O—C1-C6-alkyl, —CN, —CF3, —OCF3, halogen, and ═O, wherein R1 is —H; wherein R2 is selected from among —H, -halogen, —CN, —O—C1-C4-alkyl, —C1-C4-alkyl, —CH═CH2, —C≡CH, -cyclopropyl, —CF3, —OCF3, —OCF2H, and —OCFH2; wherein R3 is —H; wherein R6 is selected from among —H, —C1-C4-alkyl, —OH, —O—C1-C4-alkyl, -halogen, —CN, —CF3, and —OCF3; wherein Z is C; wherein n is 2; wherein R4 and R5 are independently selected from among an electron pair, —H, and a group selected from among —C1-C6-alkyl, —NH2, —C3-C8-cycloalkyl, —C3-C8-heterocyclyl, —C5-C10-aryl, -C5-C10-heteroaryl, and —C(O)—N(R8,R8′), with R8 and R8′ independently being selected from among —H, and —C1-C6-alkyl, and wherein R4 and R5 if different from an electron pair or —H are optionally independently substituted with one or more groups selected from among -halogen, —OH, —CF3, —CN, —C1-C6-alkyl, —O—C1-C6-alkyl, —O—C3-C8-cycloalkyl, —O—C3-C8-heterocyclyl, —O—C5-C10-aryl, —O—C5-C10-heteroaryl, —C0-C6-alkylene-CN, —C0-C4-alkylene-O—C1-C4-alkyl, —C0-C4-alkylene-O—C3-C8-cycloalkyl, —C0-C4-alkylene-O—C3-C8-heterocyclyl, —C0-C4-alkylene-O-C5-C10-aryl, —C0-C4-alkylene-O-C5-C10-heteroaryl, —C0-C4-alkylene-Q-C0-C4-alkyl-N(R9,R9′), —C0-C4-alkylene-N(R10)-Q-C1-C4-alkyl, —C0-C4-alkylene-N(R10)-Q-C3-C8-cycloalkyl, —C0-C4-alkylene-N(R10)-Q-C3-C8-heterocyclyl, —C0-C4-alkylene-N(R10)-Q-C5-C10-aryl, —C0-C4-alkylene-N(R10)-Q-C5-C10-heteroaryl, —C0-C4-alkylene-Q-N(R11,R11′), —C0-C4-alkylene-N(R12)-Q-N(R13,R13′), —C0-C4-alkylene-R14, —C0-C4-alkylene-Q-C1-C6-alkyl, —C0-C4-alkylene-Q-C3-C8-cycloalkyl, —C0-C4-alkylene-Q-C3-C8-heterocyclyl, —C0-C4-alkylene-Q-C5-C10-aryl, —C0-C4-alkylene-Q-C5-C10-heteroaryl, —C0-C4-alkylene-O-Q-N(R15,R15′), and —C0-C4-alkylene-N(R16)-Q-O—(R17), wherein Q is selected from among —C(O)—, and —SO2—, wherein R12, R16, are independently selected from among —H, —C1-C6-alkyl, and —C3-C6-cycloalkyl, wherein R9, R9′, R10, R11, R11′, R13, R13′, R15, R15′, are independently selected from among —H, —C1-C6-alkyl, and —C3-C6-cycloalkyl, or wherein R9 and R9′, R11 and R11′, R13 and R13′, R15 and R15′ together form a —C2-C6-alkylene group, wherein R14 and R17 are independently selected from among —H, —C1-C6-alkyl, —C5-C10-aryl, —C5-C10-heteroaryl, —C3-C8-cycloalkyl, and —C3-C8-heterocyclyl, wherein said —C3-C8-heterocyclyl optionally comprises nitrogen and/or —SO2— in the ring, and wherein R14 and R17 are optionally substituted with one or more groups selected from among —OH, —OCH3, —CF3, —OCF3, —CN, -halogen, —C1-C4-alkyl, ═O, and —SO2—C1-C4-alkyl, or wherein R4 and/or R5 are independently selected from among an electron pair, —H, and a group of the structure -L2-R18, wherein L2 is selected from among —NH— and —N(C1-C4-alkyl)-, wherein R18 is selected from among —C5-C10-aryl, —C5-C10-heteroaryl, —C3-C8-cycloalkyl, and —C3-C8-heterocyclyl, wherein R18 is optionally substituted by one or more groups selected from among halogen, —CF3, —OCF3, —CN, —OH, —O—C1-C4-alkyl, —C1-C6-alkyl, —NH—C(O)—C1-C6-alkyl, —N(C1-C4-alkyl)-C(O)—C1-C6-alkyl, —C(O)—C1-C6-alkyl, —S(O)2—C1-C6-alkyl, —NH—S(O)2—C1-C6-alkyl, —N(C1-C4-alkyl)-S(O)2—C1-C6-alkyl, and —C(O)—O—C1-C6-alkyl, and wherein R4, R5 and R18 are optionally further substituted by spiro-C3-C8-cycloalkyl or spiro-C3-C8-heterocyclyl such that together with R4, R5 and/or R18 a spirocycle is formed, wherein said spiro-C3-C8-heterocyclyl optionally comprises one or more groups selected from among nitrogen, —C(O)—, —SO2—, and —N(SO2—C1-C4-alkyl)- in the ring, or wherein R4, R5 and R18 are optionally further bi-valently substituted by one or more spirocyclic or annellated ring forming groups selected from among —C1-C6-alkylene, —C2-C6-alkenylene, and —C4-C6-alkynylene, in which one or two carbon centers may optionally be replaced by one or two hetero atoms selected from among N, O and S and which may optionally be substituted by one or more groups on one ring atom or on two neighbouring ring atoms selected from among —OH, —NH2, —C1-C3-alkyl, O—C1-C6-alkyl, —CN, —CF3, —OCF3, and halogen; or a pharmacologically acceptable salt thereof. |