| 发明名称 | Modulator | ||
| 摘要 | There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject. | ||
| 申请公布号 | US8962032(B2) | 申请公布日期 | 2015.02.24 |
| 申请号 | US201013515884 | 申请日期 | 2010.12.17 |
| 申请人 | The Queen's University of Belfast | 发明人 | Scott Christopher;Johnston James;Spence Shaun;McAuley Danny;Fay Francois |
| 分类号 | A61P11/00;A61P31/06;A61P11/06;A61P11/08;A61P31/00;A61P9/00;A61P37/00;A61P3/10;A61P25/00;A61K9/14;A61K31/702;A61K47/48;A61K45/06 | 主分类号 | A61P11/00 |
| 代理机构 | Winstead PC | 代理人 | Winstead PC |
| 主权项 | 1. A method of modulating an inflammatory response in a cell, the method comprising: providing sialic acid presented on a microparticle or nanoparticle to a cell such that a proinflammatory response is suppressed through reduction of TNF alpha levels or an anti-inflammatory response is increased through an increase in IL-10 levels in the cell, and wherein the sialic acid is NeuAcα2-8NeuAc. | ||
| 地址 | Belfast GB | ||