摘要 |
<p>The present invention relates to a method for treating chronic obstructive pulmonary disease in a mammalian subject, which comprises administering an effective amount of a specific bicyclic compound of formula (I): (see formula I) wherein A1 and A2 are the same or different halogen atoms and B is -COOH, including its pharmaceutically acceptable salts, ethers, esters or amides and/or a tautomer thereof to a subject in need thereof.</p> |