METODO PARA LA GENERACION DE MODELOS REALISTAS EN TRES DIMENSIONES DE CELULAS NEURONALES

摘要

The present invention relates to a method for the generation of 3-dimensional models of neuronal cells based on incomplete morphological information extracted by means of standard sampling methods. The models generated include a realistic soma, dendritic and axonal trees and dendritic spines, which may be generated at different resolution levels. The invention proposes an innovative technique that makes it possible to obtain a realistic soma form based on a simple definition thereof (such as centre and radius), which is incomplete for reconstruction of the original 3D form. The proposed method is based on deformation of an initial shape, guided by restrictions established in accordance with the morphological properties of the dendritic and axonal trees (e.g. position and thickness of the first-order dendrites). The distribution of a set of spines along the dendrites completes the model, generating a 3-dimensional model suitable for viewing in a wide range of 3D environments.