INSULIN-LIKE GROWTH FACTOR I RECEPTOR ANTIBODIES AND USING THEM

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to biotechnology. What is presented is a composition of antibodies possessing an IGF-IR binding capacity and prepared by culturing a CHO DSM ACC 2795 cell line with an amount of fucose residues in a sugar chain of the antibodies making at least 99%. What is also disclosed is a pharmaceutical composition for tumour growth inhibition and a method for preparing the above pharmaceutical composition by mixing a composition of the antibodies according to the invention with a pharmaceutically acceptable carrier.EFFECT: composition of the antibodies possesses a low antibody-dependent cell-mediated cytotoxicity (ADCC) and can be used in the therapy of IGF-IR associated diseases.5 cl, 1 dwg, 4 tbl, 15 ex