发明名称 |
METHOD OF TREATING PROSTATE CANCER WITH USING PROLONGED PRODRUG OF OCTREOTIDE ACCOMPANYING SURGICAL OR DRUG-INDUCED CASTRATION |
摘要 |
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to oncourology, and can be used in the non-surgical treatment of the patients suffering early stages of prostate malignant tumour. A method of treating prostate cancer with using prolonged prodrug of octreotide accompanying surgical or drug-induced castration involves a) measuring pre-therapeutic prostate-specific antigen; b) measuring pre-therapeutic blood plasma chromogranin A; c) selecting the patients having high blood chromogranin A of more than 3 nmol/l; d) conducting a therapy with prolonged prodrug of octreotide in a combination with dexamethasone in the selected patients; e) controlling the prostate-specific antigen variation every month and monitoring a decrease thereof in the patients by measuring it intra-therapeutically according to the stage d); the therapeutic efficacy according to the stage d) is evaluated by a therapeutic response, which is accompanied by maximum decrease of the prostate-specific antigen.EFFECT: invention enables providing the higher therapeutic efficacy in the patients suffering prostate cancer at the different stages.3 cl, 1 tbl, 5 ex |
申请公布号 |
RU2541810(C2) |
申请公布日期 |
2015.02.20 |
申请号 |
RU20130123500 |
申请日期 |
2013.05.23 |
申请人 |
ZAKRYTOE AKTSIONERNOE OBSHCHESTVO "FARM-SINTEZ" |
发明人 |
NAZARENKO ANNA BORISOVNA;APOLIKHIN OLEG IVANOVICH;SIVKOV ANDREJ VLADIMIROVICH;EFREMOV GENNADIJ DMITRIEVICH;RABINOVICH EHDUARD ZINOV'EVICH;KESHISHEV NIKOLAJ GEORGIEVICH;KOVCHENKO GRIGORIJ ALEKSANDROVICH;PROKHOROV SERGEJ ARKAD'EVICH;SOKOV DMITRIJ GENNAD'EVICH;NIKONOVA LARISA MARBEKOVNA |
分类号 |
G01N33/49;A61K35/00 |
主分类号 |
G01N33/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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