主权项 |
1. A composition comprising a glucagon analog, wherein said analog comprises a formula of sequential α-amino acids (α) and at least one β-amino acid (β) chosen from: ααααααβ, αααααβα, ααααβαα, αααβααα, ααβαααα, αβααααα, βαααααα, αααααββ, ααααββα, αααββαα, ααββααα, αββαααα, ββααααα, βαααααβ, βααααβα, βαααβαα, βααβααα, βαβαααα, αβααααβ, αβαααβα, αβααβαα, αβαβααα, ααβαααβ, ααβααβα, ααβαβαα, αααβααβ, αααβαβα, and ααααβαβ, wherein the analog is a fusion polypeptide comprising a first and a second amino acid sequence, and wherein the first amino acid sequence is derived from a glucagon amino acid sequence and the second amino acid sequence is derived from glucagon-like peptide-1 (GLP-1). |