SYSTEMS AND METHODS FOR PARTICLE RADIATION ENHANCED DELIVERY OF THERAPY

摘要

Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.

主权项

1. An in vivo agent delivery vehicle comprising:
a nano structure; an in vivo agent comprising a layer arranged around the exterior of the nanostructure such that the in vivo-agent can be durably entrained within living tissue and wherein bombardment with a selected dose of particle radiation releases the in vivo agent from the nano structure; and an outer coating such that the in vivo agent layer is interposed between the nanostructure and the outer coating.