ANHYDRATE OF TIOTROPIUM BROMIDE

摘要

The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.

主权项

1. A process for the preparation of anhydrous tiotropium bromide, comprising the steps of:
(a) providing a solution of scopine di-(2-thienyl)glycolate and a first organic solvent; (b) adding a solution of methyl bromide in a second organic solvent to the mixture from step (a) or vice versa; (c) isolating anhydrous tiotropium bromide from the mixture obtained in step (b); and (d) drying the isolated anhydrous tiotropium bromide.