METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE

摘要

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect Chitinase-3-like protein 1 as a predictive biomarker in renal injuries.

主权项

1. A method for evaluating renal status in a subject, comprising:
performing an assay configured to detect Chitinase-3-like protein 1 on a body fluid sample obtained from the subject by introducing the body fluid sample into an assay instrument that (i) contacts all or a portion of the body fluid sample with a binding reagent which specifically binds for detection Chitinase-3-like protein 1, and (ii) generates an assay result indicative of binding of Chitinase-3-like protein 1 to the binding reagent; and correlating the assay result to the renal status of the subject by using the assay result to a likelihood of to assign the patient to a predetermined subpopulation of individuals having a known predisposition of one or more future changes in renal status selected from the group consisting of a future injury to renal function, future reduced renal function, future improvement in renal function, and future acute renal failure (ARF).