NMDA RECEPTOR MODULATORS AND USES THEREOF

摘要

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

主权项

1. A compound represented by: wherein R11, R12 and R13 are each independently selected from the group consisting of H, halogen, C1-3alkoxy, and C1-3alkyl (optionally substituted by one, two or three halogens); X1 is OH or NH2, X2 is H or OH; and pharmaceutically acceptable salts, stereoisomers and hydrates thereof.