Verfahren zur Herstellung von substituierten 1,2,4-Triazolen

摘要

Process for preparing cpds. (I) R3 = amino, alkylamino, arylamino, aralkylamino, aryloxy, cyano, rhodano, mercapto, alkylmercapto, arylmercapto or aralkylmercapto R5 = one of the groups R3 or H The cpds. are biologically active or are useful intermediates for the synthesis of biologically active substances. 5.2 Parts (II) X3 = Cl, X5 = H was dissolved in 50 pts. aniline and refluxed for 5 hrs. Excess aniline was removed by distillation and the residue washed with 100 pts. ether. The residue was then recrystallised from water to give a 95% yield of (I) R3 = anilino, R5 = H, m.pt. 168-170 deg.C.