发明名称 |
REGIOSELECTIVE SILYL EXCHANGE OF PER-SILYLATED OLIGOSACCHARIDES |
摘要 |
The present invention provides novel, regioselectively-acylated oligosaccharide compounds and methods for preparing them. In another aspect, the. invention provides a method for preparing a selectively-acylated oligosaccharide. The method includes forming a reaction mixture containing a protected oligosaccharide and an acylating agent. The protected oligosaccharide includes at least three hydroxyl moieties and each hydroxyl moiety is protected with a silyl protecting group. The reaction mixture is formed under conditions sufficient to selectively replace at least one silyl protecting group with a -C(0)-C1_6 alkyl group, and the selectively-acylated oligosaccharide comprises at least one -C(0)-C1_6 alkyl group and at least one silyl protecting group. |
申请公布号 |
WO2014205115(A3) |
申请公布日期 |
2015.02.19 |
申请号 |
WO2014US43006 |
申请日期 |
2014.06.18 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GERVAY-HAGUE, JACQUELYN;SCHOMBS, MATTHEW |
分类号 |
A61K31/70 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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