主权项 |
1. A compound represented by Formula I, its individual enantiomers, individual diastereoisomers, individual tautomers or a pharmaceutically acceptable salt thereof wherein: A is substituted or unsubstituted C6-10 aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted C3-8 cycloalkyl, or substituted or unsubstituted C3-8 cycloalkenyl; B is substituted or unsubstituted C6-10 aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted C3-8 cycloalkyl, or substituted or unsubstituted C3-8 cycloalkenyl; R1 is H, halogen, —OR7, C1-8 alkyl, CN, C(O)R8 or NR9R10; R2 is H, halogen, —OR7, C1-8 alkyl, CN, C(O)R8 or, NR9R10; R3 is H, halogen, —OR7, C1-8 alkyl, CN, C(O)R8 or NR9R10; R4 is H, halogen, —OR7, C1-8 alkyl, CN, C(O)R8 or NR9R10; R5 is H, halogen, —OR7, C1-8 alkyl, CN, C(O)R8 or NR9R10; R6 is H, halogen, —OR7, C1-8 alkyl, CN, C(O)R8 or NR9R10; L1 is O, S, NR11 or CH2; R7 is H or C1-8 alkyl; R8 is H, —OC1-8 alkyl, OH, NR11R12 or C1-8 alkyl; a is 0, 1, 2, 3, 4 or 5; R9 is H or C1-8 alkyl; R10 is H or C1-8 alkyl; R11 is H or C1-8 alkyl; and R12 is H or C1-8 alkyl. |