1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT
摘要
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
申请公布号
WO2015023355(A1)
申请公布日期
2015.02.19
申请号
WO2014US42560
申请日期
2014.06.16
申请人
GENENTECH, INC.
发明人
FLYGARE, JOHN A.;PILLOW, THOMAS H.;SAFINA, BRIAN;VERMA, VISHA;WEI, BINQING;DENNY, WILLIAM;GIDDENS, ANNA;LEE, HO;LU, GUO-LIANG;MILLER, CHRISTIAN;REWCASTLE, GORDON;TERCEL, MOANA;BONNET, MURIEL
