发明名称 T CELL RECEPTORS
摘要 The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted CLGGLLTMV peptide derived from the LMP2A protein from Epstein Barr Virus (EBV). TCRs of the invention comprise a TCR alpha chain variable domain and/or a TCR beta variable domain. Certain preferred TCRs also bind the natural peptide variants SLGGLLTMV and CLGGLITMV presented as a peptide-HLA-A2 complex. The TCRs of the invention demonstrate excellent specificity profiles for those LMP2A epitopes and have binding affinities for the complex which result in an enhanced ability to recognize the complex compared to a soluble reference TCR having the extracellular sequence of the native EBV LMP2A TCR alpha chain given in Figure 3 (SEQ ID No: 4) and the extracellular sequence of the native EBV LMP2A TCR beta chain given in Figure 4 (SEQ ID No: 5)
申请公布号 WO2015022520(A1) 申请公布日期 2015.02.19
申请号 WO2014GB52464 申请日期 2014.08.12
申请人 IMMUNOCORE LIMITED 发明人 SU, QIN;MOLLOY, PETER;LIDDY, NATHANIEL
分类号 C07K14/05 主分类号 C07K14/05
代理机构 代理人
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