SMALL MOLECULE ACTIVATORS OF NRF2 PATHWAY

摘要

Anti-inflammatory effects of NRF2/KEAP1/ARE pathway activation compounds that repress expression of inflammatory markers and reduce levels of TNFa demonstrating the neuroprotective anti-inflammatory potential of NRF2 activator in the CNS. The compounds provided herein are high affinity reversible binders of the NRF2 inhibitor, KEAP1. These compounds treat of a number of diseases, including Huntington's disease, Parkinson's disease, Alzheimer's disease, inflammation, and cancer.