发明名称 |
Monoclonal antibody against human midkine |
摘要 |
<p>It is found that a monoclonal antibody capable of recognizing at least two amino acid residues among amino acid residues located at position-69, position-79, position-81 and position-102 in human midkine has excellent reactivity with human midkine and an excellent activity of neutralizing human midkine. It is observed that the antibody having excellent neutralizing activity as mentioned above also has an activity of inhibiting the proliferation of a tumor. The use of the antibody according to the present invention enables the effective treatment of cancer and the efficient detection or purification of midkine.</p> |
申请公布号 |
AU2013297478(A1) |
申请公布日期 |
2015.02.19 |
申请号 |
AU20130297478 |
申请日期 |
2013.07.30 |
申请人 |
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY;MEDICAL & BIOLOGICAL LABORATORIES CO., LTD. |
发明人 |
KADOMATSU, KENJI;KISHIDA, SATOSHI;ONO, KENICHIRO;YAGI, KASUMI |
分类号 |
C12N15/09;A61K39/395;A61P35/00;C07K16/18;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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