PHARMACEUTICAL COMBINATIONS

摘要

A pharmaceutical combination comprising (a) a phosphatidylinositol-3-kinase (PI3K) inhibitor compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof and (b) lomustine or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use, for the treatment of a brain tumor, particularly glioblastoma multiforme; a pharmaceutical composition comprising said combination; the use of said combination for the preparation of a medicament for the treatment of a brain tumor; a method of treating or preventing a brain tumor comprising administering a jointly therapeutically effective amount of such a combination to a subject in need thereof; and a commercial package thereof.