DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS
摘要
In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (ll).
申请公布号
WO2015023879(A1)
申请公布日期
2015.02.19
申请号
WO2014US51127
申请日期
2014.08.14
申请人
WILLIAM MARSH RICE UNIVERSITY;BRISTOL-MYERS SQUIBB COMPANY;THE SCRIPPS RESEARCH INSTITUTE
发明人
NICOLAOU, KYRIACOS, C.;LU, MIN;MANDAL, DEBASHIS;GANGWAR, SANJEEV;CHOWDARI, NAIDU, S.;POUDEL, YAM, B.