发明名称 |
4,4-DIFLUORO-PIPERIDINE-COMPOUNDS |
摘要 |
The invention, in a first aspect relates to compounds of formula (I);;or a pharmaceutically acceptable salt thereof, wherein
R is a 6-membered aromatic ring, or a 5- or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O and N, or a 6-membered benzocondensed heteroaromatic ring containing N as heteroatom, optionally each of said rings being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl, cyano, trifluoromethyl, dimethylamino, or phenyl which optionally is substituted with one or more halogen atoms, or a 5- or 6-membered heterocycle containing from one to three nitrogen atoms;X is O or N;P is pyridyl, pyrimidyl, pyrazyl, or pyridazyl, each being optionally substituted with one or more substituents selected from the group consisting of (C1-C3)alkyl, halogen, trifluoromethyl, and cyano, and use thereof as pharmaceuticals. |
申请公布号 |
US2015051226(A1) |
申请公布日期 |
2015.02.19 |
申请号 |
US201314381815 |
申请日期 |
2013.02.28 |
申请人 |
ROTTAPHARM BIOTECH S.R.L. |
发明人 |
Stasi Luigi Piero;Rovati Lucio;Artusi Roberto;Bovino Clara;Colace Fabrizio;Mandelli Stefano |
分类号 |
C07D401/14;C07D401/12;C07D417/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein
R isa 6-membered aromatic ring,a 5- or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O and N, ora 6-membered benzocondensed heteroaromatic ring containing N as heteroatom, optionally each of said rings being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl, cyano, trifluoromethyl, dimethylamino, or phenyl which optionally is substituted with one or more halogen atoms, or a 5- or 6-membered heterocycle containing from one to three nitrogen atoms;
X is O or N; P is pyridyl, pyrimidyl, pyrazyl, or pyridazyl, each being optionally substituted with one or more substituents selected from the group consisting of (C1-C3)alkyl, halogen, trifluoromethyl, and cyano. |
地址 |
MONZA IT |