| 摘要 |
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:;;wherein R1, R2, R3, and G are defined herein. |
| 主权项 |
1. A compound of Formula (I)wherein
R1 is i) phenyl optionally independently substituted with one to three substituents that are selected from the group consisting of chloro, fluoro, bromo, cyano, trifluoromethyl, C1-4alkyl, difluoromethoxy, and C1-4alkoxy; provided that when phenyl of group (i) is substituted with a single substituent, that substituent is at the 4-position; ii) a heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, pyridazinyl, and pyrazinyl; wherein said heteroaryl is optionally independently substituted with one or two substituents that are chloro, fluoro, bromo, cyano, trifluoromethyl, C1-4alkyl, or C1-4alkoxy; iii) pyrimidin-5-ylmethyl; iv) phenylmethyl, wherein the phenyl portion of phenylmethyl is optionally independently substituted with one or two substituents that are selected from the group consisting of chloro, fluoro, bromo, cyano, trifluoromethyl, C1-4alkyl, and C1-4alkoxy; provided that when phenylmethyl of group (iv) is substituted with a single substituent, that substituent is at the 4-position; v) phenylsulfonyl, wherein the phenyl portion of phenylsulfonyl is optionally independently substituted with one or two substituents that are selected from the group consisting of chloro, fluoro, bromo, cyano, trifluoromethyl, C1-4alkyl, and C1-4alkoxy; provided that when phenylsulfonyl of group (v) is substituted with a single substituent, that substituent is at the 4-position; vi) C1-4alkylsulfonyl; vii) C3-7cycloalkylsulfonyl; or viii) trifluoromethylsulfonyl; R2 is i) phenyl optionally substituted with a substituent that is selected from the group consisting of C1-4alkoxy and trifluoromethoxy; ii) a heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, thiazolyl, triazolyl, and pyrazinyl; wherein said heteroaryl is optionally substituted with a substituent that is C1-4alkyl, C1-4alkoxy, trifluoromethoxy, or hydroxy; iii) C3-7cycloalkyl; or iv) C3-7cycloalkyl-(C1-2)alkyl; R3 is selected from the group consisting of hydrogen, chloro, or methyl; G is G1, G2, or G3,and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof. |
