发明名称 |
S0X9, prostaglandin D2 and retinoic acid for treating pigmentary conditions and melanoma |
摘要 |
<p>A method of treating a hypopigmentary condition in a subject comprising administering to the subject an amount of SOX9 sufficient to treat melanoma is disclosed. The hypopigmentary condition can be a result of surgery, trauma or vitiligo. A method of treating a hyperpigmentary condition in a subject comprising administering to the subject an amount of inhibitor of SOX9 activity sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising administering to the subject an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising increasing the amounts of retinoic acid and SOX9 in the subject by amounts sufficient to treat melanoma. A method of treating melanoma in a subject comprising administering to the subject an amount of prostaglandin D2 (PGD2) and retinoic acid (RA) sufficient to treat cancer. A method of sensitizing a melanoma cell to RA comprising administering to the subject an amount of SOX9 sufficient to decrease PRAME expression. A method of increasing p21 expression in a subject comprising administering to the subject an amount of SOX9 sufficient to increase p21 expression. Methods of screening for compounds that treat hypopigmentary conditions and/or melanoma are provided.</p> |
申请公布号 |
AU2008360658(B2) |
申请公布日期 |
2015.02.19 |
申请号 |
AU20080360658 |
申请日期 |
2008.08.15 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY |
发明人 |
HEARING, VINCENT J.;PASSERON, THIERRY |
分类号 |
A61P35/00;A61K38/17;C07K14/47 |
主分类号 |
A61P35/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|