发明名称 |
MUTATIONS IN CALMODULIN GENES |
摘要 |
<p>The present invention relates to an isolated polynucleotide encoding at least a part of calmodulin and an isolated polypeptide comprising at least a part of a calmodulin protein, wherein the polynucleotide and the polypeptide comprise at least one mutation associated with a cardiac disorder. The present invention also relates to a method for determining whether an individual has an increased risk of contracting a cardiac disorder, a method for diagnosing a cardiac disorder, method for treatment of an individual having a cardiac disorder, method for identifying a compound, capable of enhancing the binding of calmodulin to ryanodine receptor 2 and use of such compound in a treatment of an individual having a cardiac disorder. The invention further provides a kit that can be used to detect specific mutations in calmodulin encoding genes.</p> |
申请公布号 |
EP2836509(A1) |
申请公布日期 |
2015.02.18 |
申请号 |
EP20130716780 |
申请日期 |
2013.04.12 |
申请人 |
AARHUS UNIVERSITET;AALBORG UNIVERSITET |
发明人 |
OVERGAARD, MICHAEL TOFT;NYEGAARD, METTE;BØRGLUM, ANDERS |
分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|