Detoxified Escherichia coli immunogens

摘要

Detoxified variants of the pathogenic E . coli 'AcfD precursor' (orf3526) have been identified that raise a substantially similar immune response in a subject as the native AcfD (orf3526) protein. The detoxified variants may be further modified to have increased solubility as compared to the native AcfD (orf3526) protein