发明名称 |
Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate |
摘要 |
Provided are a hot-melt extrudate excellent in uniform miscibility with a drug; and a method for producing a hot-melt extrudate capable of smoothly feeding a powder in hot-melt extrusion. More specifically, provided are hypromellose acetate succinate (HPMCAS) for use as a hot-melt extrusion carrier having a volume average particle size (D 50 ) of from 70 to 300 µm as measured by dry laser diffraction and a loose bulk density of from 0.25 to 0.40 g/cm 3 ; and a hot-melt extrusion composition comprising the HPMCAS and a drug. Also provided is a method for producing a hot-melt extrudate comprising the steps of: hot-melting the hot-melt extrusion composition at a hot-melt temperature equal to or higher than a melting temperature of the HPMCAS, or at a hot-melt temperature equal to or higher than a temperature at which both of the HPMCAS and the drug become melt; and extruding the hot-melted composition. |
申请公布号 |
EP2837391(A1) |
申请公布日期 |
2015.02.18 |
申请号 |
EP20140178879 |
申请日期 |
2014.07.29 |
申请人 |
SHIN-ETSU CHEMICAL CO., LTD. |
发明人 |
Maruyama, Naosuke;Warashina, Shogo;Kusaki, Fumie;Obara, Sakae;Kikuchi, Kazuki |
分类号 |
A61K9/14;A61K9/20;A61K31/4422;A61K47/38 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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