Methods, systems and devices for optical stimulation of target cells using an optical transmission element

摘要

Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one such device, target cells are stimulated using an implantable device. The device includes a light source for producing light from electrical power. An optical transmission element is made from a material that is substantially transparent to the light from the light source. This transmission element substantially encases the light source at a proximal end. The transmission element delivers light from the light source to a distal end. The shape and size of the transmission element facilitates implanting of the element within a patient. A fixation portion physically couples to the optical transmission element and secures the device to the patient. A heat dissipation portion removes heat from the near optical transmission element and the light source and dissipates the removed heat through the fixation portion.

主权项

1. A method for stimulating target cells in vivo, the method comprising:
(a) engineering one or more in vivo target cells to express a light-activated ion channel or a light activated ion pump in the cell, or a variant of ChR2 or NpHR; (b) implanting a device under a skin surface in vivo, wherein the device comprises:
(i) a light source for producing light from electrical power,(ii) an optical transmission element made from a material that is substantially transparent to the light from the light source, the material having an elongated shape that substantially encases the light source at a proximal end and that is for delivering the light from the light source to a distal end,(iii) a fixation portion physically coupled to the optical transmission element for attachment in vivo, and(iv) a heat dissipation portion having a thermally conductive path for removing heat from near the light source; (c) attaching the fixation portion of the device in vivo; and (d) activating the light source to stimulate the target cells in vivo.