| 主权项 |
1. A compound having the structure (I) or an N-oxide, N,N′-dioxide, N,N′,N″-trioxide, or a pharmaceutically acceptable saltthereof:wherein:
Q is O; W is C6-C12 aryl; X is absent; Y is NH; Z1 and Z2 are N; Z3 is NRS, wherein R5 is hydrogen or C1-C6 alkyl; R1 is C3-C12 heteroaryl having 1-3 heteroatoms; optionally substituted with hydrogen, halogen, C1-C6 alkyl, —CF3, —OH, C1-C6 alkoxy, —NR10R11, and —SOmR12, wherein R10 and R11 are independently selected from a group consisting of hydrogen, C1-C6 alkyl, —SO2R12, —S(O)R12, and —COR12 and R12 is C1-C6 alkyl or C3-C12 heteroaryl having 1-3 heteroatoms and m is 0, 1 or 2; each R2 and R3 are independently selected from a group consisting of C1-C6 alkoxy, C1-C6 alkyl, C3-C12 cycloalkyl, and halogen; p is 1 or 2; or, optionally, R2 and R3 are joined to form a five to seven membered carbocycle; R4 is independently selected from a group consisting of hydrogen, halogen, C1-C6 alkyl; and n is 1 or 2. |
