Ophthalmic compositions based on polyunsaturated omega-3 and omega-6 fatty acids

摘要

The invention concerns topical compositions for the prevention and treatment of ocular pathologies, in particular inflammatory keratites and conjunctivites and dry eye syndrome, containing as active ingredients polyunsaturated fatty acids of the types omega-3 and omega-6, and specifically EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and GLA (γ-linolenic acid), mixed with vitamin E acetate and formulated in a stable composition in hydrogel, i.e. in dispersed form in an aqueous vehicle containing one or more gelling polymers. The proposed compositions are particularly indicated for use as artificial tears.

主权项

1. A topical ophthalmic composition containing, as active ingredients, one or more omega-3 polyunsaturated fatty acids and one or more omega-6 polyunsaturated fatty acids, the said fatty acids having an aliphatic chain of from 16 to 24 carbon atoms, or pharmaceutically acceptable derivatives thereof, selected from their esters with C1-C6 alkyl groups, their triglycerides and their phospholipids, in solution with α-tocopheryl acetate, said solution being dispersed in a hydrogel that comprises an aqueous vehicle containing one or more gelling polymers comprising cross-linked carboxyvinyl polymers.