Deacetylase inhibitor therapy

摘要

The present invention relates to deacetylase inhibitor (e.g., histone deacetylase inhibitor) therapies and demonstrates that individuals with low electrolyte levels may have increased susceptibility to certain unwanted side effects such as cardiac side effects. In some embodiments, the invention provides methods of administering DAC or DAC inhibitor therapy that includes electrolyte supplementation.

主权项

1. A method for treating a Hodgkin lymphoma, myeloma, or myelodysplastic syndrome in a patient comprising intravenously administering to the patient a unit dose of romidepsin over a time period of over 30 to 60 minutes.