Vaccine vectors and methods of enhancing immune responses

摘要

Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.

主权项

1. A vaccine vector comprising a first polynucleotide sequence encoding an antigenic polypeptide and a second polynucleotide sequence encoding an immunostimulatory polypeptide, wherein the vaccine vector is a bacterial vaccine vector, wherein the immunostimulatory polypeptide is an HMGB1 polypeptide, and wherein the antigenic polypeptide and the HMGB1 polypeptide are present on the surface of the vaccine vector.