| 发明名称 |
Short interfering ribonucleic acid (siRNA) for oral administration |
| 摘要 |
Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification. |
| 申请公布号 |
US8957041(B2) |
申请公布日期 |
2015.02.17 |
| 申请号 |
US201213651808 |
申请日期 |
2012.10.15 |
| 申请人 |
Novartis AG |
发明人 |
Natt Francois Jean-Charles;Billy Eric;Hunziker Juerg;Schnell Christian Rene |
| 分类号 |
C12N15/11;C07H21/04;C12N15/113 |
主分类号 |
C12N15/11 |
| 代理机构 |
|
代理人 |
Wu Frank |
| 主权项 |
1. A method for the inhibition of a target gene in a cell comprising the step of:
introducing into the cell a short interfering ribonucleic acid (siRNA) which is capable of inhibiting the target gene by RNA interference, wherein said siRNA comprises two RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein the 3′-terminus of at least one strand comprises a modification at the 3′ carbon, wherein the modification is: |
| 地址 |
Basel CH |
