| 发明名称 | Human recombinant growth and differentiaton factor-5 (rhGDF-5) | ||
| 摘要 | Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhGDF-5 protein. Methods for production and high expression of rhGDF-5 protein are disclosed herein. The methods of enhancing production and protein expression of rhGDF-5 protein as disclosed are cost-effective, time-saving and are of manufacturing quality. | ||
| 申请公布号 | US8956829(B2) | 申请公布日期 | 2015.02.17 |
| 申请号 | US201313750524 | 申请日期 | 2013.01.25 |
| 申请人 | Warsaw Orthopedic, Inc. | 发明人 | Scher David S.;Harrington Roger E. |
| 分类号 | C12N15/09;C12N15/12;C12N15/19;C12N15/63;C12N15/70;C12N15/71;C07K14/475 | 主分类号 | C12N15/09 |
| 代理机构 | Sorell Leuna & Schmidt LLP | 代理人 | Sorell Leuna & Schmidt LLP |
| 主权项 | 1. An expression vector comprising a T5 promoter operably linked to a polynucleotide sequence that encodes a GDF-5 protein, wherein the GDF-5 protein is a human GDF-5 (rhGDF-5) protein comprising the amino acid sequence of SEQ ID NO: 4. | ||
| 地址 | Warsaw IN US | ||