| 发明名称 | Roles for Dual Endothelin-1/Angiotensin II Receptor (Dear) in hypertension and angiogenesis | ||
| 摘要 | The present application is directed to the identification of mutations and/or polymorphisms in the Dual Endothelin-1/Angiotensin II Receptor (Dear) that indicate susceptibility to, or show current affliction with, hypertension. Additionally, the present invention discloses methods for the modulation of angiogenesis via the regulation of Dear. | ||
| 申请公布号 | US8956609(B2) | 申请公布日期 | 2015.02.17 |
| 申请号 | US201414164641 | 申请日期 | 2014.01.27 |
| 申请人 | Trustees of Boston University | 发明人 | Herrera Victoria L. M.;Ruiz-Opazo Nelson |
| 分类号 | A61K39/00;C12Q1/68;C07K16/28 | 主分类号 | A61K39/00 |
| 代理机构 | Nixon Peabody LLP | 代理人 | Nixon Peabody LLP ;Eisenstein Ronald I.;Karttunen Contarino Leena H. |
| 主权项 | 1. A method for inhibiting angiogenesis in an individual comprising administering to the individual an anti-Dual Endothelin-1/Angiotensin II receptor (Dear) antibody or antibody fragment which binds to Dear and inhibits the binding of ET-1 ligand. | ||
| 地址 | Boston MA US | ||