Fused bicyclic pyridine and pyrazine derivatives as kinase inhibitors

摘要

A series of fused bicyclic pyridine and pyrazine derivatives, substituted directly on the pyridine or pyrazine ring by a functional group attached via a sulphur-containing linkage, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

主权项

1. A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein
M represents the residue of an optionally substituted phenyl ring;W represents C—R1;E represents an optionally substituted straight or branched C1-4 alkylene chain;Q represents N—R2;Z represents an optionally substituted mono- or bicyclic heteroaryl group containing at least one nitrogen atom selected from pyrrolyl, pyridinyl, indolyl, quinolinyl, isoquinolinyl, imidazolyl, pyrazolyl, triazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, indazolyl, benzimidazolyl, furopyridinyl, thienopyridinyl, benzoxazolyl, benzothiazolyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, imidazopyridinyl, pyrazolopyridinyl, purinyl, pyrazolopyrimidinyl, pyrrolopyrimidinyl, triazolopyrimidinyl, pyridopyrimidinyl, pyridopyrazinyl, pyridopyridazinyl, naphthyridinyl, pteridinyl, pyrrolotriazinyl and pyrazolotriazinyl;Y represents —S—;R1 represents hydrogen, halogen, C1-6 alkyl or C1-6 alkoxy;R2 represents hydrogen or C1-6 alkyl; andRa represents trifluoromethyl; or C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents.