Polypeptides with affinity for heat shock proteins (HSPS) and HSP associated complexes (HACS) and their use in diagnosis and therapy

摘要

The present application is directed to a peptides comprising an a-helix forming-amino acid sequence that binds a heat shock protein. Also included is a polypeptide comprising (a) a first peptide portion that comprises an α-helix-forming amino acid sequence that binds a heat shock protein; and (b) at least one second peptide portion comprising an antigenic amino acid sequence and/or an a-helix-stabilizing amino acid sequence that increases the interaction of the first peptide portion with the heat shock protein. The present application also includes compositions comprising the peptides and/or polypeptides of present application and uses of the peptides and/or polypeptides of the present application for fractionating substances relevant for discovery, research or clinical analysis from a biological sample and as therapeutics.

主权项

1. A polypeptide comprising:
(a) a first peptide portion consisting of an α-helix-forming amino acid sequence of myelin basic protein having the amino acid sequence of PSQGKGRGLSLSRFSWGA [SEQ ID NO 2:] or a sequence having one amino acid deletion, addition or substitution relative to [SEQ ID NO 2]; and (b) at least one second peptide portion comprising a tumour associated antigen (TAA) epitope of survivin at least 8 amino acids in length or a sequence having one amino acid deletion, or substitution relative to the epitope of survivin.